The exercise marks the countries' first joint air force drill since President Donald Trump began his second term.
A B-2 stealth bomber is ready to fly again after finishing its maintenance nearly 100 days ahead of schedule.
Central Command said the attacks hit missiles and other weapons components used by the militia group.
It was not until the 1944 introduction of the P-51 Mustang that B-17s would be regularly accompanied by fighter escorts.
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